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. 2022 Jul 6;13(7):583. doi: 10.1038/s41419-022-05047-6

Fig. 2. Pol β deficiency exacerbates the inflammatory response and pyroptosis in CIA mice.

Fig. 2

A, B qRT-PCR analysis of IL-1β mRNA expression in the spleen, thymus, and arthrosis of control and CIA mice. Data points indicate individual mice. Data present mean ± SD from at least 6 mice. *P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA. C, D ELISA quantitation of IL-1β protein in the serum and arthrosis of Pol β +/+-NC, Pol β +/+-CIA and Pol β +/−-CIA mice. E, F ELISA quantitation of IL-1β protein in the serum and arthrosis of Pol β WT-NC, Pol β WT-CIA, and Pol β R137Q-CIA mice. G–J qRT-PCR analysis of GSDMD and NLRP3 mRNA expression in the ankles of control and CIA mice. Data points indicate individual mice, data present mean ± SD from at least 6 mice. *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA (G–J). K, L Western blot of NLRP3 and GSDMD-N in the ankles of control and CIA mice. β-tubulin was used as an internal control.