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. 2022 Jul 6;12:11401. doi: 10.1038/s41598-022-15390-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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OXTR is produced by and present in the endopiriform nucleus (EPN) across development in mice. (A) Previously unpublished autoradiographic images selected from prior work by Hammock and Levitt (2013) demonstrate OXTR ligand binding in the EPN from birth in C57BL/6J mice. White arrowheads in A and A′ (4 × zoom) point to the dorsal EPN in the coronal plane at post-natal day 0 (P0), P7, P14, P21, P35, and P60. OXTR ligand binding was present in both males and females at all ages examined. (A″) There were no significant differences across age or sex. All ages were significantly different from adult OXTR knock-out (n = 3 per age/sex, relative binding mean ± S.E.M., ***p < 0.001). (B) Sagittal view of Oxtr-EGFP reporter mouse at P21 (enhanced with immunofluorescence for EGFP, counterstained with DAPI) demonstrates the expression of the EGFP reporter throughout the rostro-caudal extent of the EPN. (C) There is no EGFP signal in a transgene negative sample. White arrowheads in B and C show the EPN at P21. Scale bar = 0.5 mm.