Table 4.

Summary of samples carrying GBA coding variants detected in 1kGP, PD and LBD cohorts.

		p.N409S	Severe* variants	Total	Total excluding p.N409S
1kGP	N = 2504	3	14	53	50
PD	case N = 2325	128	38	296	171
	control N = 1255	158	9	200	43
	OR (95% CI)	n/a	2.12 (1.07–4.71)	n/a	2.07 (1.48–2.95)
LBD	case N = 2598	59	79	353	298
	control N = 1941	19	2	86	67
	OR (95% CI)	n/a	30.83 (9.71–187.55)	n/a	3.68 (2.82–4.87)

^*Severe and mild variants are defined in Supplementary Table 5.