Table 1.
Participant clinical and pathological characteristics (N=404).
| 1 | 404 (100%) |
| 2 | 298 (73.8%) |
| 3 | 224 (55.4%) |
| 4 | 164 (40.6%) |
| 5 | 111 27.5%) |
| 6 | 67 (16.5%) |
| 7 | 49 (12.1%) |
| 8 | 27 (6.7%) |
| 9 | 9 (2.2%) |
| 10 | 4 (1.0%) |
| mean = 3.5 (SD=2.4) | |
| AGE AT DEATH (YEARS; M, SD) | 90.6 (5.8) |
| AGE AT LAST ACTIGRAPHY VISIT (YEARS; M, SD) | 88.5 (6.1) |
| SEX (% FEMALE, N) | 72.1% (280) |
| EDUCATION (YEARS; M, SD) | 14.6 (2.8) |
| COGNITIVE DIAGNOSIS AT DEATH (N, %) | |
| CLINICALLY NORMAL | 36.3% (141) |
| MCI-AD ☨ | 24.2% (94) |
| MCI-OTHER | 1.8% (7) |
| DEMENTIA-AD ☨ | 33.2% (129) |
| DEMENTIA-OTHER | 4.4% (17) |
| AVERAGE LATE LIFE LIFESTYLE FACTORS | |
| ACTIGRAPHY: AVERAGE DAILY (COUNTS; M, SD) | 1.97 (1.1) |
| MOTOR FUNCTION COMPOSITE (Z-SCORE; M, SD) | 0.87 (0.17) |
| DEPRESSIVE SYMPTOMS (CES-D; M, SD) | 1.4 (1.3) |
| COGNITIVE ACTIVITY (POSSIBLE RANGE 1 TO 5; M, SD) | 2.98 (0.63) |
| SOCIAL ACTIVITY (POSSIBLE RANGE 1 TO 5; M, SD) | 2.34 (0.46) |
| NEUROPATHOLOGICAL EXAMINATION | |
| POSTMORTEM INTERVAL (HOURS; M, SD) | 8.2 (5.1) |
| ALZHEIMER’S DISEASE PATHOLOGY (%, REAGAN CRITERIA, N) | 64.6% (250) |
| BRAIN TISSUE SYNAPTIC PROTEINS (GLOBAL Z-SCORE)☨☨ | |
| COMPLEXIN-I (M, SD) | −0.20 (0.74) |
| COMPLEXIN-II (M, SD) | −0.17 (0.67) |
| SYNAPTOPHYSIN (M, SD) | −0.19 (0.92) |
| SNAP-25 (M, SD) | −0.18 (0.92) |
| SYNTAXIN (M, SD) | −0.18 (0.93) |
| VAMP (M, SD) | −0.18 (0.95) |
| SYNAPTOTAGMIN-1 (M, SD) | 0.02 (0.95) |
☨
NINCDS consensus criteria for possible or probable AD
☨☨
Brain synaptic protein values are expressed in log10 units, standardized to the MAP sample, and averaged across six regions within each participant (z-score units reported).
Note. All lifestyle factors represent an average of participants values across visits to capture illustrate robust indicators of late life behaviors. MCI = Mild Cognitive Impairment; AD = Alzheimer’s disease; CES-D = Center for Epidemiologic Studies – Depression scale. M = mean; SD = standard deviation.