Table 3.
The relationship between in-vivo physical activity and brain tissue synaptic protein levels at death depends on time between measurements.
| Synaptophysin | Synaptotagmin1 | Syntaxin | VAMP | SNAP-25 | Complexin-I | Complexin-II | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | |
| Average Physical Activity (n=404) | 0.11 (0.04) | 0.13* | 0.11 (0.05) | 0.13* | 0.10 (0.12) | 0.12* | 0.12 (0.05) | 0.15** | 0.10 (0.04) | 0.12* | 0.05 (0.03) | 0.07 | 0.02 (0.03) | 0.04 |
| Actigraphy ≤1yr to death (n=93) | 0.37 (0.11) | 0.36** | 0.35 (0.11) | 0.34** | 0.33 (0.11) | 0.32** | 0.36 (0.11) | 0.34** | 0.39 (0.11) | 0.38** | 0.28 (0.08) | 0.35** | 0.03 (0.08) | 0.04 |
| Actigraphy 1–2yr to death (n=119) | 0.24 (0.08) | 0.31** | 0.26 (0.08) | 0.32** | 0.19 (0.08) | 0.24* | 0.22 (0.08) | 0.26** | 0.21 (0.08) | 0.27** | 0.15 (0.06) | 0.26* | −0.06 (0.16) | −0.1 |
| Actigraphy 3–4yr to death (n=134) | 0.07 (0.06) | 0.11 | 0.06 (0.06) | 0.09 | 0.04 (0.06) | 0.06 | 0.07 (0.07) | 0.10 | 0.05 (0.06) | 0.07 | 0.02 (0.06) | 0.03 | 0.01 (0.05) | 0.03 |
| Actigraphy 5–6yr to death (n=101) | −0.003 (0.05) | −0.005 | −0.01 (0.05) | −0.02 | 0.01 (0.05) | 0.02 | −0.01 (0.05) | −0.02 | −0.46 (0.31) | −0.09 | −0.01 (0.05) | −0.16 | −0.09 (0.12) | −0.15 |
| Actigraphy 9–10yr to death (n=33) | −0.29 (0.17) | −0.37 | −0.24 (0.18) | −0.31 | −0.12 (0.18) | −0.16 | −0.22 (0.17) | −0.28 | −0.14 (0.16) | −0.2 | −0.18 (0.13) | −0.31 | −0.17 (0.11) | −0.31 |
Note.
*
p<0.05;
**
p<0.01;
each column represents a regression model. Average Late Life Actigraphy models adjusted for age at death, sex, education, and average late life motor10 performance. All other models adjusted for age at visit, sex, education and motor10 performance at visit.