Table 4.
Models demonstrating the size of the relationship between physical activity and brain tissue synaptic protein levels appears similar across brain regions.
| Synaptophysin | Synaptotagmin1 | Syntaxin | VAMP | SNAP-25 | Complexin-I | Complexin-II | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | Coeff (se) | Std Beta | |
| Average Late Life Actigraphy (all participants, n=404) | ||||||||||||||
| Striatal | 0.14 90.05) | 0.16** | 0.15 (0.05) | 0.17** | 0.10 (0.05) | 0.12* | 0.16 (0.05) | 0.18** | 0.12 (0.05) | 0.14* | 0.05 (0.04) | 0.06 | 0.02 (0.04) | 0.03 |
| Hippo | 0.10 (0.05) | 0.12* | 0.11 (0.05) | 0.13* | 0.10 (0.05) | 0.11* | 0.11 (0.05) | 0.12* | 0.09 (0.05) | 0.11 | 0.08 (0.05) | 0.09 | 0.01 (0.05) | 0.01 |
| Cortical | 0.10 (0.05) | 0.12* | 0.10 (0.05) | 0.11* | 0.09 (0.05) | 0.10 | 0.11 (0.05) | 0.13* | 0.10 (0.05) | 0.12* | 0.06 (0.04) | 0.07 | 0.02 (0.04) | 0.03 |
| Occipital | 0.12 (0.05) | 0.14* | 0.13 (0.05) | 0.15** | 0.11 (0.05) | 0.13* | 0.13 (0.05) | 0.15** | 0.12 (0.05) | 0.14* | 0.05 (0.05) | 0.05 | 0.07 (0.05) | 0.08 |
| Actigraphy 0–2yr to death (n=150) | ||||||||||||||
| Striatal | 0.27 (0.07) | 0.33** | 0.27 (0.07) | 0.32** | 0.22 (0.07) | 0.28** | 0.26 (0.08) | 0.30** | 0.22 (0.07) | 0.27** | 0.12 (0.07) | 0.16 | −0.07 (0.06) | −0.10 |
| Hippo | 0.29 (0.07) | 0.34** | 0.32 (0.08) | 0.37** | 0.26 (0.07) | 0.31** | 0.25 (0.08) | 0.31** | 0.29 (0.08) | 0.34** | 0.30 (0.08) | 0.33** | −0.01 (0.07) | −0.01 |
| Cortical | 0.26 (0.07) | 0.31** | 0.26 (0.08) | 0.31** | 0.22 (0.07) | 0.27** | 0.23 (0.08) | 0.27** | 0.25 (0.07) | 0.30** | 0.18 (0.07) | 0.23** | −0.03 (0.07) | −0.04 |
| Occipital | 0.28 (0.07) | 0.33** | 0.29 (0.08) | 0.33** | 0.24 (0.08) | 0.30** | 0.27 (0.07) | 0.32** | 0.28 (0.08) | 0.32** | 0.17 (0.08) | 0.20* | 0.01 (0.08) | 0.01 |
| Actigraphy 3+yr to death (n=154) | ||||||||||||||
| Striatal | 0.17 (0.08) | 0.21* | 0.20 (0.08) | 0.25** | 0.13 (0.07) | 0.17 | 0.23 (0.07) | 0.30** | 0.15 (0.08) | 0.19 | 0.13 (0.07) | 0.16 | 0.02 (0.07) | 0.03 |
| Hippo | 0.13 (0.08) | 0.15 | 0.21 (0.08) | 0.26** | 0.14 (0.08) | 0.17 | 0.17 (0.07) | 0.22* | 0.17 (0.08) | 0.20* | 0.08 (0.09) | 0.09 | 0.001 (0.08) | 0.001 |
| Cortical | 0.14 (0.08) | 0.17 | 0.17 (0.08) | 0.21* | 0.11 (0.08) | 0.13 | 0.19 (0.08) | 0.23* | 0.15 (0.08) | 0.18 | 0.11 (0.07) | 0.15 | 0.02 (0.07) | 0.03 |
| Occipital | 0.09 (0.08) | 0.10 | 0.17 (0.08 | 0.20* | 0.10 (0.08) | 0.12 | 0.16 (0.08) | 0.18 | 0.09 (0.08) | 0.11 | 0.11 (0.08) | 0.14 | 0.08 (0.08) | 0.10 |
Note.
*
p<0.05;
**
p<0.01;
Average Late Life Actigraphy models adjusted for age at death, sex, education, and average late life motor10 performance. All other models adjusted for age at visit, sex, education and motor10 performance at visit. “Cortical” represents middle frontal and inferior temporal gyri. Hippo = hippocampal.