Table 1:
Baseline Participant Characteristics
| Baseline Demographics | N= 2314 |
|---|---|
| Clinical Characteristics | |
| Age, years | 54 (9) |
| Caucasian, N (%) | 2110 (91) |
| BMI, kg/m2 | 28.2 (5.4) |
| Smoking status | |
| Never, N(%) | 1420 (61) |
| Former, N(%) | 758 (33) |
| Current, N(%) | 136 ( 6) |
| Hypertension, N(%) | 1104 (48) |
| Diabetes, N(%) | 177 ( 8) |
| Emphysema on imaging, N (%) | 65 (5) |
| ILA on imaging, N (%) | 20 (1) |
| Physical Activity Score (PAI), mean (SD) | 34 (6) |
| Pulmonary Function Measures | |
| FEV1 (L) | 3.40 (0.76) |
| % predicted FEV1 | 102 (14) |
| FVC (L) | 4.43 (0.99) |
| % Predicted FVC | 105 (13) |
| FEV1/FVC | 0.77 (0.06) |
| % Predicted FEV1/FVC | 95 (7) |
| DLCO, mL/min/mm Hg | 26.29 (6.06) |
| % Predicted DLCO | 97 (14) |
| CPET Measures | |
| Peak VO2 (mL/min/kg) | 22.9 (6.80) |
| OUES (mL/min/log(L/min)) | 1969 (582) |
| VO2 at AT (mL/min/kg) | 12.6 (3.6) |
| % predicted peak VO2 | 95.5 (19.9) |
| Aerobic Efficiency (mL/W/min) | 8.95 (0.95) |
| VO2/work (mL.min−1.W−1) | 10.96 (1.0) |
| Peak Borg Score | 6.81 (1.84) |
| % predicted maximum heart rate | 91 (10) |
| VE at AT ((L/min) | 24.7 (7.50) |
| Peak RER | 1.22 (0.10) |
| Oxygen pulse slope (VO2/HR) | 19.3 (7.40) |
| Breathing reserve at AT | 79.0 (5.2) |
| Breathing reserve at peak exercise (%) | 43.3(15.24) |
Abbreviations: FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; DLCO, diffusion capacity of the lungs for carbon monoxide; VO2: maximum oxygen consumption; OUES, oxygen uptake efficiency slope; VE at AT, minute ventilation at anaerobic threshold; RER, respiratory exchange ratio
*
PAI is a composite score of hours spent performing an activity and weighted oxygen consumption of the activity as previous described by Kannel et al. 11