Table 2:
Association of lung function with CPET variables
| FEV1 | FVC | FEV1/FVC | DLCO | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta est. | Se | p-value | Beta est. | se | p-value | Beta est. | se | p-value | Beta | se | p-value | |
| Peak VO2 | 0.18 | 0.03 | <0.001 | 0.20 | 0.03 | <0.001 | 0.02 | 0.02 | >0.99 | 0.28 | 0.02 | <0.001 |
| OUES | 0.12 | 0.02 | <0.001 | 0.14 | 0.03 | <0.001 | −0.001 | 0.01 | >0.99 | 0.28 | 0.02 | <0.001 |
| % predicted peak VO2 | 0.25 | 0.04 | <0.001 | 0.27 | 0.04 | <0.001 | 0.02 | 0.02 | >0.99 | 0.40 | 0.03 | <0.001 |
| VO2 at AT | 0.13 | 0.03 | <0.001 | 0.16 | 0.03 | <0.001 | −0.004 | 0.02 | >0.99 | 0.30 | 0.03 | <0.001 |
| O2 pulse slope | 0.09 | 0.03 | 0.008 | 0.10 | 0.03 | 0.007 | 0.003 | 0.01 | >0.99 | 0.16 | 0.02 | <0.001 |
| VO2/work | −0.07 | 0.03 | 0.99 | −0.06 | 0.03 | >0.99 | −0.02 | 0.02 | >0.99 | 0.05 | 0.03 | >0.99 |
| %predicted HR | 0.09 | 0.04 | 0.53 | 0.11 | 0.04 | 0.14 | −0.01 | 0.02 | >0.99 | 0.19 | 0.03 | <0.001 |
| VE AT | 0.16 | 0.03 | <0.001 | 0.20 | 0.03 | <0.001 | −0.01 | 0.02 | >0.99 | 0.22 | 0.03 | <0.001 |
| Peak RER | 0.08 | 0.04 | >0.99 | 0.02 | 0.04 | >0.99 | 0.06 | 0.02 | 0.11 | −0.09 | 0.03 | 0.41 |
| BR AT | 0.75 | 0.03 | <0.001 | 0.59 | 0.04 | <0.001 | 0.25 | 0.02 | <0.001 | −0.03 | 0.03 | >0.99 |
| BR peak | 0.51 | 0.03 | <0.001 | 0.40 | 0.04 | <0.001 | 0.17 | 0.02 | <0.001 | −0.04 | 0.03 | >0.99 |
*
Analyses were adjusted for age, sex, smoking status (never, current former), hypertension, height (inches), weight (kg), diabetes mellitus, and Framingham cohort. P-values include Bonferroni correction to account for multiple testing and were evaluated at a 5% level of significance. Beta represents the standard-deviation difference in response variable (CPET measures) per 1-standard deviation change in predictor variable (raw lung function measure).
Abbreviations: VO2: maximum oxygen consumption; OUES, oxygen uptake efficiency slope; VE at AT, minute ventilation at anaerobic threshold; RER, respiratory exchange ratio