Table 1.
Viral vectored TB vaccine candidates that are currently in clinical trials.
| Candidate vaccines | Vectors | Antigens | Populations/animals | Clinical trial phases | Clinical trialstatus | Sponsors/inventors | References/clinical trial registry numbers |
|---|---|---|---|---|---|---|---|
| MVA85A i.d. | MVA | Ag85A | BCG-vaccinated healthy infants | IIb | Completed | Aeras, University of Oxford | 37/NCT00953927 |
| MVA85A i.d. | MVA | Ag85A | Adults infected with HIV-1 | II | Completed | Aeras, University of Oxford | 50/NCT01151189 |
| MVA85A i.m. | MVA | Ag85A | BCG-vaccinated healthy adolescents | II | Completed | University of Oxford | NCT02178748 |
| ChAdOx1.85A i.m. -MVA85A i.m. | ChAdOx1/MVA | Ag85A | Healthy adults and adolescents | II | Active, not recruiting | University of Oxford | NCT03681860 |
| AERAS-402 i.m. | AdHu35 | Ag85A, Ag85B, TB10.4 | Adults treated for pulmonary TB | II | Completed | Aeras, Crucell | NCT02414828 |
| AERAS-402 i.m. | AdHu35 | Ag85A, Ag85B, TB10.4 | HIV-infected, BCG-vaccinated adults | II | Completed | Aeras, Crucell | NCT01017536 |
| AERAS-402 i.m. | AdHu35 | Ag85A, Ag85B, TB10.4 | BCG-vaccinated healthy infants | II | Completed | Aeras, Crucell | NCT01198366 |
| TB/FLU-04L aerosol | FLU-04L | ESAT-6 | BCG-vaccinated healthy adults | IIa | Unknown | Research Institute for Biological Safety Problems | NCT02501421 and unkown |
| AdAg85A aerosol | AdHu5 | Ag85A | BCG-vaccinated healthy adults | Ib | Completed | McMaster University | 70/NCT02337270 |
| AdAg85A i.m. | AdHu5 | Ag85A | BCG-naïve and -vaccinated healthy adults | I | Terminated | McMaster University | 69/NCT00800670 |
| MVA85A aerosol | MVA | Ag85A | BCG-vaccinated healthy adults | I | Completed | University of Oxford | 51/NCT01497769 |
| MVA85A aerosol-MVA85A i.d. | MVA | Ag85A | BCG-vaccinated healthy adults | I | Completed | University of Oxford | 52/NCT01954563 |
| MVA85A aerosol | MVA | Ag85A | Healthy adults with latent TB infection | I | Completed | University of Oxford, University of Birmingham | 53/NCT02532036 |
| AERAS-402 i.m.-MVA85A i.d. | AdHu35/MVA | Ag85A | BCG-vaccinated healthy adults | I | Completed | University of Oxford, Aeras, Crucell | 55/NCT01683773 |
| MVA85A i.d.-FP85A i.d. | MVA/FP9 | Ag85A | BCG-vaccinated healthy adults | I | Completed | University of Oxford | 57/NCT00653770 |
| MVA85A i.d.-IMX313 i.d. | MVA/nanoparticle | Ag85A | BCG-vaccinated healthy adults | I | Completed | University of Oxford | 58/NCT01879163 |
i.d., intradermal; i.m., intramuscular.