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. 2022 Jun 23;12:913432. doi: 10.3389/fonc.2022.913432

Figure 1.

Figure 1

Glycosylation alterations in human pan-cancer. (A) Study flowchart. (B) PCA projection of paired tumor and normal tissue samples from 11 different cancer types in TCGA. Different colors represent different cancer types. Circles and triangles represent normal and tumor tissue, respectively. (C) Heatmap showing glycosylation-related pathway alterations across 11 cancer types. MsigDB, molecular signatures database; PCA, principal component analysis; HCC, hepatocellular carcinoma; GSVA, gene set variance analysis; CNV, copy number variation; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; HNSC, head and neck squamous cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; OV, ovarian serous cystadenocarcinoma; PRAD, prostate adenocarcinoma; UCEC, uterine corpus endometrial carcinoma.