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. 2022 Jun 23;12:913432. doi: 10.3389/fonc.2022.913432

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Copyright © 2022 Liu, Zhou and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The immune landscape of HCC tumors in TCGA-LIHC. (A, B) Classification of low- and high-risk HCC tumors into C1–C6 classes. C1, wound healing; C2, IFN-γ dominant; C3, inflammatory; C4, lymphocyte depleted; C6, TGF-β dominant. (C) Heatmap of Spearman’s correlation between transcriptome profiles, risk scores, and immune infiltration. Only statistically significant correlations are shown (P <0.05). (D) Spearman’s correlation of Th2/Th17 infiltration, M0/M1 macrophage infiltration, and the glycosylation-based risk score. (E, F) Different relative proportions of immune cells in different groups. (G) Scores of the five distinct immune indices between the low- and high-risk groups. *P <0.05; **P <0.01; ***P < 0.001, ns, not significant.