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. 2022 Jun 23;16:882559. doi: 10.3389/fnins.2022.882559

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Copyright © 2022 Ail, Samardzija, Chang, Keck, Reddel and Grimm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upregulation of Stc2 upon stabilization of HIF1A in rod photoreceptors. Relative expression of Stc1 (green bars) and Stc2 (blue bars) in rod^Δ^Vhl, rod^Δ^Vhl;Hif¹^a, rod^ΔVhl;Hif2a, and rod^Δ^Vhl;Hif¹^a;Hif²^a mice and their control lines that carried the respective floxed genes without Opsin-cre (–). Expression was determined by semi-quantitative real-time PCR and normalized to Actb levels. Shown are mean values ± SD of N = 3. ****P < 0.0001. Two-way ANOVA with Sidak’s multiple comparison test.