Table 4.
Comparison of the ICSI outcomes of NOA patients with different etiologies.
| Idiopathic(n=112) | Orchitis(n=37) | Klinefelter`s Syndrome (n=80) | AZFc Microdeletions(n=31) | Cryptorchidism(n=39) | P-value | |
|---|---|---|---|---|---|---|
| Male`s age (yr.) | 32.48 ± 5.45 | 32.22 ± 4.42 | 30.05 ± 4.22 | 31.03 ± 3.93 | 31.46 ± 4.01 | 0.009* |
| Female`s age (yr.) | 29.50 ± 4.06 | 30.68 ± 4.30 | 27.94 ± 4.16 | 28.42 ± 3.16 | 29.38 ± 3.60 | 0.006* |
| Male’s FSH (IU/L) | 16.14 ± 10.16 | 22.16 ± 10.56 | 24.00 ± 11.29 | 19.72 ± 9.46 | 16.59 ± 9.76 | 0.000* |
| No. of MII oocytes for ICSI | 11.79 ± 10.98 | 11.95 ± 6.91 | 10.69 ± 5.45 | 8.97 ± 4.78 | 9.79 ± 3.71 | 0.329 |
| No. of available embryos on day3 | 3.73 ± 3.50 | 3.68 ± 3.00 | 2.61 ± 1.85 | 2.00 ± 2.07 | 2.67 ± 1.88 | 0.003* |
| No. of high-score embryos on day 3 | 1.06 ± 1.36 | 1.05 ± 1.15 | 0.76 ± 0.93 | 0.26 ± 0.51 | 0.77 ± 0.99 | 0.006* |
| Day 3 utilization rate of MII eggs for ICSI %1 | 31.7 (418/1320) | 30.8 (136/442) | 24.4 (209/855) | 22.3 (62/278) | 27.2 (104/382) | 0.000* |
| Rate of high-score embryo on day 3%2 | 14.9 (119/801) | 14.7 (39/266) | 11.7 (61/522) | 4.4 (8/180) | 12.2 (30/246) | 0.003* |
| No. of cycles without available embryos/ICSI cycles (%) | 13.4 (15/112) | 5.4 (2/37) | 8.8 (7/80) | 25.8 (8/31) | 7.7 (3/39) | 0.062 |
| Sperm quantity (%) | / | / | / | / | / | 0.011* |
| ≤20 sperms | 15.2 (17/112) | 13.5 (5/37) | 31.2 (25/80) | 35.5 (11/31) | 15.4 (6/39) | / |
| >20 sperms | 84.8 (95/112) | 86.5 (32/37) | 68.8 (55/80) | 64.5 (20/31) | 84.6 (33/39) | / |
| Sperm motility rate (%, mean ± SD) | 13.69 ± 9.96 | 11.46 ± 9.93 | 12.53 ± 11.23 | 10.23 ± 9.88 | 16.07 ± 10.71 | 0.118 |
| Pregnancy | / | / | / | / | / | / |
| No. of patients with clinical pregnancy/undergoing ICSI cycles with available embryos (%) | 58.8 (57/97) | 62.9 (22/35) | 57.5 (42/73) | 30.4 (7/23) | 61.1 (22/36) | 0.113 |
| No. of patients with clinical pregnancy/undergoing ICSI cycles (%) | 50.9 (57/112) | 59.5 (22/37) | 52.5 (42/80) | 22.6 (7/31) | 56.4 (22/39) | 0.021* |
| No. of patients with clinical pregnancy/successful sperm retrieval (%) | 42.0 (68/162) | 63.8 (30/47) | 46.6 (54/116) | 14.3 (7/49) | 46.6 (27/58) | 0.000* |
| Live birth | / | / | / | / | / | / |
| No. live birth/clinical pregnancy (%) | 91.2 (52/57) | 95.5 (21/22) | 95.2 (40/42) | 85.7 (6/7) | 95.5 (21/22) | 0.805 |
| Singleton (%) | 86.5 (45/52) | 90.5 (19/21) | 92.5 (37/40) | 66.7 (4/6) | 81.0 (17/21) | 0.378 |
| Twins (%) | 13.5 (7/52) | 9.5 (2/21) | 7.5 (3/40) | 33.3 (2/6) | 19.0 (4/21) | 0.095 |
| No. live birth/undergoing ICSI cycles with available embryos (%) | 53.6 (52/97) | 60.0 (21/35) | 54.8 (40/73) | 26.1 (6/23) | 58.3 (21/36) | |
| No. live birth/undergoing ICSI cycles (%) | 46.4 (52/112) | 56.8 (21/37) | 50.0 (40/80) | 19.4 (6/31) | 53.8 (21/39) | 0.018* |
| No. live birth/successful sperm retrieval (%) | 37.0 (60/162) | 57.4 (27/47) | 44.8 (52/116) | 12.2 (6/49) | 44.8 (26/58) | 0.000* |
| No. premature infants/live birth (%) | 15.4 (8/52) | 14.3 (3/21) | 25.0 (10/40) | 50.0 (3/6) | 9.5 (2/21) | 0.150 |
| No. cesarean delivery/live birth (%) | 36.5 (19/52) | 42.9 (9/21) | 22.5 (9/40) | 33.3 (2/6) | 23.8 (5/21) | 0.412 |
| No. birth defects/live birth (%) | 1.9 (1/52) | 0 | 2.5 (1/40) | 0 | 0 | 0.892 |
| Gender | / | / | / | / | / | 0.906 |
| Male (%) | 42.4 (25/59) | 34.8 (8/23) | 34.9 (15/43) | 37.5 (3/8) | 44.0 (11/25) | / |
| Female (%) | 57.6 (34/59) | 65.2 (15/23) | 65.1 (28/43) | 62.5 (5/8) | 56.0 (14/25) | / |
| Birth weighBirth weight (g) | / | / | / | / | / | / |
| Singleton (n =122) | 3254.44 ± 396.96 | 3178.68 ± 398.13 | 3063.51 ± 478.25 | 2995.00 ± 528.93 | 3239.71 ± 301.16 | 0.252 |
| Twins (n =18, 36 babies) | 2156.43 ± 419.94 | 2495.00 ± 82.26 | 2459.17 ± 265.87 | 2411.25 ± 87.21 | 2402.50 ± 209.61 | 0.152 |
| Height (cm) | / | / | / | / | / | / |
| Singleton (n =122) | 49.84 ± 2.04 | 49.53 ± 2.82 | 49.41 ± 2.42 | 48.00 ± 2.45 | 50.29 ± 1.21 | 0.352 |
| Twins (n =18, 36 babies) | 44.36 ± 3.78 | 48.00 ± 3.16 | 45.83 ± 3.37 | 44.25 ± 0.96 | 45.25 ± 3.01 | 0.381 |
Data are expressed as mean ± SD unless indicated otherwise.
1 and 2, the definitions see Table 1 .
* Significantly different.