TABLE 3.

Comparison of changes in oxygenated hemoglobin during verbal fluency test between patients with MDD and suicidality and those without suicidality.

(Unit: μ mol)	MDD without suicidality (n = 31)		MDD with suicidality (n = 23)		RM-ANOVA			RM-ANCOVAa			Permutation test
	Mean	SD	Mean	SD	F	p	p for interactionb	F	p	p for interactionb	p
Total prefrontal cortex	0.491	1.071	0.167	0.847	0.966	0.331	0.342	0.823	0.371	0.408	0.172
Right prefrontal cortex	0.687	1.317	0.150	1.010	1.544	0.221	0.669	1.623	0.211	0.523	0.090
Left prefrontal cortex	0.295	0.895	0.185	0.803	0.237	0.629	0.092	0.055	0.816	0.333	0.615
Right DLPFC	0.703	1.641	0.303	1.265	0.714	0.403	0.508	0.864	0.359	0.526	0.196
Right VLPFC	1.392	1.905	0.333	1.728	2.901	0.096	0.922	5.028	0.031	0.808	0.054
Right FPC	0.412	1.133	−0.019	0.809	1.687	0.201	0.473	1.221	0.277	0.233	0.140
Right VMPFC	0.366	1.177	−0.043	1.087	0.257	0.615	0.425	0.035	0.854	0.546	0.290
Left DLPFC	0.369	1.094	0.325	1.094	0.425	0.518	0.151	0.075	0.786	0.543	0.882
Left VLPFC	0.751	1.111	0.253	0.940	2.266	0.140	0.454	1.345	0.254	0.930	0.084
Left FPC	0.324	1.200	−0.007	0.768	0.937	0.338	0.328	0.521	0.475	0.352	0.154
Left VMPFC	−0.125	1.138	0.266	0.824	1.935	0.171	0.359	2.448	0.127	0.293	0.293

MDD, major depressive disorder; DLPFC, dorsolateral prefrontal cortex; VLPFC, ventrolateral prefrontal cortex; FPC, frontopolar cortex; VMPFC, ventromedial prefrontal cortex.

^aAdjusted by age, sex, systolic blood pressure, heart rate, alcohol intake, smoking status, and years of education.

^bp-values for interactions between time (visit) and group.