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. 2022 Jun 23;13:904618. doi: 10.3389/fphys.2022.904618

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Copyright © 2022 Dünnwald, Paglia, Weiss, Denti, Faulhaber, Schobersberger and Wackerhage.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic overview of most important metabolic pathways. Changes of selected metabolites related to glycolysis, betta-oxidation, TCA-cycle, urea cycle and branched-chain amino acids (BCAA) at day 8 after hypoxic exercise are shown. Metabolites coloured as green and red represent metabolites that were upregulated and downregulated at day 8 after exercise, respectively. Metabolites marked as black represent detected metabolites whereas grey indicates non-detected metabolites. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 for significant increases (B) or decreases (C) in associated metabolites on day 8 post exercise.