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. 2022 Jun 23;15:911122. doi: 10.3389/fnmol.2022.911122

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Copyright © 2022 Ishibashi, Yoshikawa, Sueto, Tashima, Tozaki-Saitoh, Koga, Yamaura and Tsuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ablation of AAV-PdynP⁺ spinal dorsal horn (SDH) neurons selectively attenuates optogenetic Aβ fiber-induced pain-like behavior after peripheral nerve injury (PNI) in rats. (A) Paw withdrawal responses to light and von Frey filaments in W-TChR2V4 rats with and without AAV-PdynP⁺ SDH neurons after PNI (n = 7–8 rats). ****P < 0.0001 vs. the ipsilateral side of DTX-treated rats, two-way repeated measures ANOVA with post-hoc Bonferroni multiple comparison test. (B) Schematic diagram for place aversion test. Rats received blue light to the plantar skin while in the black compartment. The percentage of time spent in black compartment with or without light stimulation 2 weeks after PNI in W-TChR2V4 rats with and without AAV-PdynP⁺ SDH neurons after PNI (n = 8). **P < 0.01, two-way factorial ANOVA with post-hoc Tukey's multiple comparison test. Data shown as mean ± SEM.