TABLE 4.

Efficacy of compound 6d on bicuculline-induced seizures in mice.

Compound	Dose (mg/kg)	Test time (h)	Clonic seizure (%)	Tonic seizure (%)	Lethality (%)
DMSO	—	0.5	100	100	100
Carbamazepine	30	0.5	100	0***	20**
6d	30	0.5	10**	0***	0***

Results are expressed as a percentage of animals showing clonic and tonic convulsions and death among all animals tested. The number of animals tested in each group was ten. Significance was determined with Fisher’s exact test. **p < 0.05 and ***p < 0.001 vs. group of BIC (5.4 mg/kg).