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. 2022 Jun 23;13:848915. doi: 10.3389/fphar.2022.848915

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Copyright © 2022 Xu, Zhang, Wang, Chen, Xu, Sun, Yang, Lin, Wang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of GPS on blood and urine biochemical parameters of diabetic mice. (A) Process of the experiment in vivo. (B–D) Levels of FBG, GSP, and HbAlc of experimental animals. (E,F) Levels of LDL-C and TG of experimental animals. (G) Body weight of experimental animals. (H–J) Levels of Cr, BUN, and 24 h Up of experimental animals. Data were expressed as means ± SD. n = 8. Diabetes: diabetes group; GPS (L): GPS treatment group (low dose: 50 mg/kg); GPS (M): GPS treatment group (medium dose: 100 mg/kg); GPS (H): GPS treatment group (high dose: 200 mg/kg); Val: valsartan treatment group (10 mg/kg). **p < 0.01 vs. Ctrl. ^## p < 0.01 and ^# p < 0.05 vs. diabetes.