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. 2022 Jun 23;13:848915. doi: 10.3389/fphar.2022.848915

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Copyright © 2022 Xu, Zhang, Wang, Chen, Xu, Sun, Yang, Lin, Wang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPS treatment ameliorated renal fibrosis of diabetic mice. (A) Histopathology analysis of renal tubules by HE (scale bar: 200 μm), PAS (scale bar: 200 μm), and Masson (scale bar: 200 μm) staining. (B,C) Protein levels of E-cad, vimentin, α-SMA, and FN in renal tissues of diabetic mice were detected by Western blot. (D) Protein levels of vimentin and α-SMA in renal tubules of diabetic mice were detected by immunohistochemistry. Scale bar: 25 μm. Data were expressed as mean ± SD. n = 8. **p < 0.01 vs. Ctrl. ^## p < 0.01 and ^# p < 0.05 vs. diabetes.