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. 2022 Jun 23;13:848915. doi: 10.3389/fphar.2022.848915

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Copyright © 2022 Xu, Zhang, Wang, Chen, Xu, Sun, Yang, Lin, Wang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPS downregulated the protein level of AT1R, and AT1R over-expression reversed the effect of GPS on EMT in HG-induced NRK-52E cells. (A) Expressions of AT1R under the HG conditions at various times were detected by Western blot. **p < 0.01 and *p < 0.05 vs. 0 h. (B) Protein level of AT1R after GPS intervention was detected by Western blot. **p < 0.01 vs. Ctrl. ^## p < 0.01 and ^# p < 0.05 vs. HG. (C,D) Effects of GPS on E-cad, vimentin, α-SMA, and FN expression after AT1R over-expression were detected by Western blot. **p < 0.01 vs. Ctrl. ^## p < 0.01 and ^# p < 0.05 vs. HG. ^^p < 0.05 vs. HG with GPS. (E) Effect of GPS on the migration ability after the AT1R over-expression was detected by the cell scratch test. Data were expressed as mean ± SD.