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. 2022 Jun 23;13:848915. doi: 10.3389/fphar.2022.848915

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Copyright © 2022 Xu, Zhang, Wang, Chen, Xu, Sun, Yang, Lin, Wang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AT1R over-expression reversed the effect of GPS on regulating the CK2/NF-κB pathway. (A) Effects of GPS on p65 distribution in the nucleus and cytoplasm after AT1R over-expression were detected by Western blot. (B) Effects of GPS on the DNA NF-κB p65 binding activity after the AT1R over-expression were detected by EMSA. (C) Effect of GPS on the NF-κB p65 transcriptional activity after the AT1R over-expression was detected by luciferase reporter assay. (D,E) Effects of GPS on protein expressions of p-IκBα, IκBα, and p-CK2α after AT1R over-expression was detected by Western blot. (F) Binding of CK2α and IκBα in NRK-52E was detected by immunoprecipitation. **p < 0.01 and *p < 0.05 vs. Ctrl. ^## p < 0.01 and ^# p < 0.05 vs. HG. ^^p < 0.01 and ^p < 0.05 vs. HG with GPS. Data were expressed as mean ± SD.