Table 1.
Distribution and age of diagnosis of second primary CNS tumors by whether radiation was part of the primary malignancy treatment course
| No. (%) |
Age of second primary diagnosis, median (1st to 3rd quantile), y |
|||||
|---|---|---|---|---|---|---|
| No radiation | Radiation | P value | No radiation | Radiation | P value | |
| Overall | 365 | 331 | – | 49 (30-65) | 41 (30-54) | 7.1e-5 |
| Ependymoma | 12 (3.3) | 6 (1.8) | .325 | 47 (28-64) | 43.5 (37-46) | 0.482 |
| Medulloblastoma | 7 (1.9) | 6 (1.8) | 1 | 21 (12-31) | 28 (19-50) | 0.295 |
| Pilocytic astrocytoma | 23 (6.3) | 2 (0.6) | 1.28e-4 | 20 (12-34) | 30 (22-38) | 0.581 |
| Astrocytoma | 35 (9.6) | 21 (6.3) | 0.152 | 49 (26-60) | 34 (18-44) | 0.054 |
| Oligodendroglioma | 33 (9.0) | 17 (5.1) | 0.065 | 39 (33-55) | 48 (43-51) | 0.412 |
| Glioblastoma | 53 (14.5) | 68 (20.5) | 0.046 | 63 (46-70) | 45 (33-54) | 1.55e-5 |
| Other glioma | 28 (7.7) | 21 (6.3) | 0.593 | 41 (24-54) | 34 (21-44) | 0.322 |
| Lymphoma | 4 (1.1) | 2 (0.6) | – | 82.5 (78-86) | 55.5 (48-63) | 0.133 |
| Meningioma | 88 (24.1) | 142 (42.9) | 2.19e-7 | 61 (48-75) | 40.5 (29-53) | 7.54e-13 |
| Nerve sheath | 27 (7.4) | 14 (4.2) | 0.107 | 40 (18-60) | 38.5 (31-63) | 0.492 |
| Other histology | 55 (15.1) | 32 (9.7) | 0.042 | 41 (21-58) | 46 (37-59) | 0.133 |
Abbreviation: CNS = central nervous system. Bold faced P-values indicate significance at P < .05.