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. 2022 Jun 23;14:922154. doi: 10.3389/fnagi.2022.922154

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Copyright © 2022 Zhang, Shang, Ye, Ling, Zhong, Zhang, Zhang, Zhang, Yu, He, Ye and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voxel-wise neurovascular comparisons between the aphasic group and control group (FDR-corrected p < 0.05) after controlling for age, sex, education level, and lesion size. Left column: clusters of warm colors indicate significant decreases in VMHC (A), CBF (B), and the CBF/VMHC ratio (C) in aphasia, respectively, with lighter colors denoting higher t-values and significance. Right column: nodes indicate subregions of the Brainnetome Atlas corresponding to significant clusters. A2, area 2; A23v, ventral area 23; A31, area 31; A39rv, rostroventral area; A40c, caudal area 40; A44d, dorsal area 44; A8vl, ventrolateral area 8; A9/46v, ventral area 9/46; CBF, cerebral blood flow; dId, dorsal dysgranular insula; dIg, dorsal granular insula; mOccG, middle occipital gyrus; pSTS, posterior superior temporal sulcus; VMHC, voxel-mirrored homotopic connectivity.