Table 1.

The methylation status summary of a cluster during disease progression is summarised using the “Methylation Colour Guide” legend. Classification is based on the clusters probes methylation status compared to the NFT disease stage.

Methylated at NFT	Methylated at STIC	Methylated at HGSC	Summary for disease progression
N	Y	Y	Methylated at STIC plus
N	N	Y	Methylated at HGSC-STIC non
N	Partial	Y	Methylated at HGSC-STIC partial
N	Y	N	Methylated temporarily at STIC
Y	N	N	De-Methylated at STIC plus
Y	Y	N	De-Methylated at HGSC-STIC
Y	Partial	N	De-Methylated at HGSC-STIC partial
Y	N	Y	De-Methylated temp at STIC
Any other combination		None of the above