Table 2.
Evaluation of the in vivo transmission-blocking activity of A3 and F1.
| PBS | DMSO | A3 | F1 | ATQ | |
|---|---|---|---|---|---|
| Mosquitoes Infected/Dissected | 29/30 | 27/30 | 17/30 | 19/30 | 10/30 |
| Prevalence of infection (%)a | 96.7 | 90.0 | 56.7 | 63.3 | 33.3 |
| Reduction in prevalence (%)b | 43.3 | 36.7 | 66.7 | ||
| Oocyst intensity (mean ± SEM)c | 193 ± 16.2 | 173 ± 17.3 | 59 ± 12.1 | 40 ± 8.0 | 15 ± 1.9 |
| Reduction in oocyst intensity (%)d | 65.9 | 76.9 | 91.3 |
Drug-administrated infected mice were fed to mosquitoes. The prevalence of infection and oocyst density were compared with the negative control group (vehicle).
a
Prevalence of the mosquito infection = infected number/dissected number × 100%.
b
Reduction of prevalence = % prevalenceControl - % prevalenceDrug.
c
The number of oocysts per midgut.
d
Reduction in oocysts density = (mean oocyst densityControl – mean oocyst densityDrugs)/mean oocyst densityControl × 100%.