Table 2.

The effect of subcutaneous semaglutide compared to that of placebo or GLP-1 RA comparator on HbA1c and body weight. Data are presented as mean difference and 95% CI.

Study ID	HbA1c difference (%) [95% CI]	P value	Weight difference (kg) [95% CI]	P value
Ahmann et al., 2018 (SUSTAIN 3) [16]	GLP = -0.62 [-0.80, −0.44]	P < 0.0001	GLP = -3.78 [-4.58, −2.98]	P < 0.0001
Capehorn et al., 2020 (SUSTAIN 10) [23]	GLP = -0.69 [-0.82, −0.56]	P < 0.0001	GLP = -3.83 [-4.57, −3.09]	P < 0.0001
Pratley et al., 2018 (SUSTAIN 7) [19]	GLP = -0.41 [-0.57, −0.25]	P < 0.0001	GLP = -3.55 [-4.32, −2.78]	P < 0.0001
Rodbard et al., 2018 (SUSTAIN 5) [18]	0.5 mg = -1.35 [-1.60, −1.10] 1.0 mg = -1.75 [-2.01, −1.49]	P < 0.0001	0.5 mg = -2.31 [-3.30, −1.32] 1.0 mg = -5.06 [-6.08, −4.04]	P < 0.0001
Sorli et al., 2017 (SUSTAIN 1) [14]	0.5 mg = -1.43 [-1.71, −1.15] 1.0 mg = -1.53 [-1.81, −1.25]	P < 0.0001	0.5 mg = -2.75 [-3.92, −1.58] 1.0 mg = -3.56 [-4.74, −2.38]	P < 0.0001
Zinman et al., 2019b (SUSTAIN 9) [20]	1.0 mg = -1.42 [-1.61, −1.23]	P < 0.0001	1.0 mg = -3.81 [-4.70, −2.92]	P < 0.0001