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. 2022 Jun 23;15:927149. doi: 10.3389/fnmol.2022.927149

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Copyright © 2022 Williams, Johnson, Lee, Hemmings and Platholi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BDNF Val66Met and Met66Met single nucleotide polymorphisms do not affect total synaptic vesicle number or amount of exocytosis. Representative images of 14–16DIV Val66Val (wt), Val66Met, and Met66Met mouse hippocampal neurons transfected with mCherry (A-top) and vGlut-pH (with NH₄Cl alkalization, A, bottom). (B) Change in fluorescence of vGlut-pH with tetanic stimulation (left) or NH₄Cl alkalization (right) reflecting amount of exocytosis or total vesicle number showed no significant differences between the three genotypes. Data are mean±SD; n = 15–22 neurons per experimental group and 750–1,100 boutons. Scale bar = 5 μm.