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. 2022 Jun 30;26(2):111–118. doi: 10.5213/inj.2142224.112

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Copyright © 2022 Korean Continence Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — UTCs from aged rats showed altered mitochondria bioenergetics. (A) Representative Seahorse trace measuring oxygen consumption in UTCs from young (open circles) and aged (squares) rats. Trace shows basal respiration, the addition of DMEM as a vehicle control, oligomycin (2.5μM), FCCP (0.7μM), and rotenone (10μM) (as described in the Methods section). (B) Quantitation of data from 2 individual experiments (N=4 rats/group) measuring basal respiration (P=0.001), maximal respiratory rate (P=0.013), and spare respiratory capacity (P=0.017). (C) Hypotonicity-evoked adenosine triphosphate release was significantly lower in UTCs from aged versus young rat bladders by 80%; N=3 each, P=0.006. UTC, urothelial cell; OCR, oxygen consumption rate; DMEM, Dulbecco’s Modified Eagle Medium; FCCP, carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone.