Table 3.
Association between nocturia (≥2 times) and mortality stratified by age and sex
| Variable | All-cause mortality |
Cardiovascular disease mortality |
||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| Age group | ||||||
| 20–60 years | 1.44 (1.08–1.92) | 0.012 | 1.87 (0.91–3.82) | 0.087 | ||
| Mild nocturia (2–3 times) | 1.28 (0.94–1.74) | 0.118 | 1.33 (0.58–3.06) | 0.497 | ||
| Moderate-to-severe nocturia (≥ 4 times) | 2.26 (1.37–3.74) | 0.001 | 5.59 (2.07–15.08) | 0.001 | ||
| Over 61 years | 1.18 (1.04–1.34) | 0.012 | 1.48 (1.12–1.96) | 0.006 | ||
| Mild nocturia (2–3 times) | 1.12 (0.98–1.29) | 0.890 | 1.47 (1.10–1.97) | 0.009 | ||
| Moderate-to-severe nocturia (≥ 4 times) | 1.52 (1.21–1.92) | < 0.001 | 1.50 (0.90–2.52) | 0.124 | ||
| Sex | ||||||
| Men | 1.28 (1.09–1.50) | 0.002 | 1.68 (1.20–2.35) | 0.002 | ||
| Mild nocturia (2–3 times) | 1.24 (1.04–1.45) | 0.015 | 1.67 (1.19–2.36) | 0.003 | ||
| Moderate-to-severe nocturia (≥ 4 times) | 1.62 (1.23–2.43) | 0.001 | 1.70 (0.92–3.14) | 0.088 | ||
| Women | 1.19 (1.00–1.42) | 0.050 | 1.41 (0.92–2.17) | 0.120 | ||
| Mild nocturia (2–3 times) | 1.10 (0.91–1.33) | 0.333 | 1.24 (0.78–1.95) | 0.362 | ||
| Moderate-to-severe nocturia (≥ 4 times) | 1.91 (1.39–2.63) | < 0.001 | 2.82 (1.41–5.01) | 0.003 | ||
Multiple Cox regression model adjusted for age, race, body mass index, smoking status, alcohol consumption, sleep duration, dyslipidemia, hypertension, and diabetes mellitus.
HR, hazard ratio; CI, confidence interval.