Figure 2.
Omicron-sublineage-neutralizing serum activity in vaccinated and convalescent individuals
(A) Study scheme in COVID-19-convalescent individuals infected between February and April 2020.
(B) Pseudovirus neutralization assay 50% inhibitory serum dilutions (ID50s) in convalescent individuals. Bars indicate geometric mean ID50s (GeoMeanID50s) with 95% confidence intervals (CIs). Numbers indicate GeoMeanID50s and fraction of individuals with detectable neutralizing activity (ID50 > 10; in parentheses).
(C) Study scheme in vaccinated individuals.
(D) Pseudovirus neutralization assay serum ID50s in vaccinated individuals. Bars indicate GeoMeanID50s with 95% CIs. Numbers indicate GeoMeanID50s and fraction of individuals with detectable neutralizing activity (ID50 > 10; in parentheses).
(E) Black numbers indicate Spearman’s rank correlation coefficients (rho) at V2. Red numbers indicate p values determined after the Friedman test by Dunn’s multiple comparison tests at V2 (statistically significant differences with p < 0.05 in bold).
In (B) and (D), ID50s below the lower limit of quantification (LLOQ, ID50 = 10; indicated by black dotted lines) were imputed to ½ × LLOQ (ID50 = 5), and ID50s above the upper limit of quantification (21,870) were imputed to 21,871. See also Figure S1 and Table S1.