Figure 4.

Omicron-sublineage-neutralizing activity of monoclonal antibodies in clinical use

(A) Neutralization dose response curves in pseudovirus-based assay. Circles show averages and error bars indicate standard deviation. Dotted lines indicate 50% neutralization (IC₅₀).

(B) IC₅₀s of antibodies in current or previous clinical use or development. Symbols indicate whether clinical products or parental antibodies produced as human IgG1 were used for neutralization testing.

(C) Neutralization dose response curves in pseudovirus-based assay. Circles show averages and error bars indicate standard deviation. Dotted lines indicate 50% neutralization (IC₅₀).

(D) IC₅₀s of antibodies in (C) against Wu01 and Omicron sublineages (upper rows) and previously circulating variants (lower rows, as previously determined; Vanshylla et al., 2022).

See also Figure S3.