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. 2022 Jun 23;9:910291. doi: 10.3389/fnut.2022.910291

Table 3.

Multivariable associations of renal damage with hydration status and physical activity level using generalized linear mixed-effects models among 6–9-year-old children in Beijing (N = 1914).

Dependent variables Independent variables Model 1 Model 2 Model 3
Estimate (95%CI) P Estimate (95%CI) P Estimate (95%CI) P
Tubular Intercept −1.16 (−1.72, −0.61) <0.001 −2.31(−3.89, −0.73) 0.004 −2.15 (−3.74, −0.56) 0.008
damage Euhydration −0.75 (−0.90, −0.59) <0.001 −0.78 (−0.93, −0.63) <0.001 −0.78 (−0.93, −0.63) <0.001
Sufficient PA −0.21 (−0.43, 0.01) 0.066 −0.20 (−0.42, 0.02) 0.074 −0.21 (−0.43, 0.02) 0.069
Interaction 0.45 (0.11, 0.79) 0.010 0.44 (0.09, 0.78) 0.012 0.43 (0.09, 0.77) 0.014
Glomerular Intercept −2.61 (−2.91, −2.30) <0.001 −3.21 (−5.80, −0.63) 0.015 −2.98 (−5.56, −0.40) 0.024
damage Euhydration −1.18 (−1.49, −0.87) <0.001 −1.28 (−1.60, −0.96) <0.001 −1.27 (−1.59, −0.95) <0.001
Sufficient PA −0.08 (−0.44, 0.28) 0.67 −0.06 (−0.43, 0.31) 0.76 −0.05 (−0.42, 0.32) 0.80
Interaction 0.60 (0.01, 1.19) 0.047 0.57 (−0.03, 1.17) 0.060 0.57 (−0.04, 1.17) 0.065

PA, physical activity; CI, confidence interval; Model 1, unadjusted; model 2, adjusting for age, sex, and BMI z–score; model 3, adjusting for age, sex, BMI z–score, standardized SBP, sleep duration, screen time, and fruit and vegetable intake. All models included two random effects, namely, the week–day and intra–wave of the urinalysis.