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. 2022 Apr 8;35:13–22. doi: 10.1016/j.jot.2022.03.002

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — (A) T + D contributes to fatty infiltration within the supraspinatus muscle demonstrated by immunofluorescence staining for perilipin and DAPI. Scale bar = 50 μm (B) The proportional areas of fat were significantly higher in the T + D group. n = 3 mice/group (C) The transcripts expression of adipocyte markers. n = 5 mice/group (D) Increase of PDGFRα⁺ MSCs in the T+D group shown by Western blotting, immunofluorescent images and semi-quantitative counting of PDGFRα⁺ cells per microscopic field (214 μ m × 214 μ m). Scale bar = 30 μm, n = 3 mice/group (E) The effect of imatinib on the suppression of fatty infiltration illustrated by immunofluorescence staining for perilipin with DAPI (scale bar = 100 μm) or laminin and PDGFRα with DAPI (scale bar = 30 μm) (n = 3 mice/group), as well as Western blotting (2 mice/group) (F) The transcripts expression of adipocyte markers after imatinib treatment. n = 5 mice/group. Values are presented as means ± SD. TT, tendon transection; DN, suprascapular nerve denervation; T + D, tendon transection and denervation. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001. Adapted and reprinted with permission from Ref. [83].