Table 3.

Example Dose Finding Table for the BOIN-ET Design.

		Cumulative Number of Responses
		0	1	2	3	4	5	6
Cumulative Number of DLTs	0	E	E	E	S	S	S	S
	1	E/S/D	E/S/D	E/S/D	S	S	S	S
	2	E/S/D	E/S/D	E/S/D	S	S	S	S
	3	D	D	D	D	D	D	D
	4	D	D	D	D	D	D	D
	5	D	D	D	D	D	D	D
	6	D	D	D	D	D	D	D

D = De-Escalate, E = Escalate, S=Stay. The target toxicity probability and efficacy probability assumed are ϕ = 0.3 and δ = 0.6 respectively. The assumed design parameters of ϕ₁ = 0.1ϕ, ϕ₂ = 1.4ϕ and δ₁ = 0.6δ lead to optimal values of λ_e, λ_d and η₁ of 0.14, 0.35 and 0.48.