Table 5.

Dosing Decision Rules for the TITE-BOIN-ET Design.

	Cumulative number of responses
Cumulative number of toxicities		0	1	2	3
	0	E	E if ESSEj >2.07 S if ESSE j ≤ 2.07	S	S
	1	E/S/D if ESSTj ≥2.87a D if ESSTj<2.87	E/S/D if ESSEj >2.07 and ESSTj ≥2.87a S if ESSEj ≤2.07 and ESSTj ≥2.87, D if ESSTj<2.87	S if ESSTj ≥2.87 D if ESST j < 2.87	S if ESSTj ≥2.87 D if ESST j < 2.87
	2	D	D	D	D
	3	D	D	D	D

E = Escalate, D = De-escalate and S=Stay.

^aThe rules used in the E/S/D cases in TITE-BOIN-ET to decide whether to escalate, de-escalate or stay at the same dose are the same as those used in BOIN-ET for the E/S/D case to decide whether to escalate, de-escalate or stay at the same dose (see BOIN-ET section).