Table 6.
Desirability score table for the BOIN Comb design with the target DLT probability of 0.3 [1].
| Number of Patients | Number of DLTs | Desirability Score |
|---|---|---|
| 0 | 0 | 6 |
| 3 | 0 | 7 |
| 3 | 1 | 11 |
| 3 | 2 | 5 |
| 3 | ≥3 | E |
| 6 | 0 | 3 |
| 6 | 1 | 13 |
| 6 | 2 | 16 |
| 6 | 3 | 10 |
| 6 | ≥4 | E |
| 9 | 0 | 2 |
| 9 | 1 | 9 |
| 9 | 2 | 17 |
| 9 | 3 | 18 |
| 9 | 4 | 12 |
| 9 | ≥5 | E |
“E”: eliminate current and higher doses.