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. 2022 Jun 23;13:916216. doi: 10.3389/fimmu.2022.916216

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Copyright © 2022 Araújo-Pereira, Barreto-Duarte, Arriaga, Musselwhite, Vinhaes, Belaunzaran-Zamudio, Rupert, Montaner, Lederman, Sereti, Madero and Andrade

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The degree of inflammatory perturbation increases in anemic participants. (A) Scatter plots of the degree of inflammatory perturbation (DIP) by sample in the main groups: non-TB (green) and TB (purple); (B) Scatter plots of DIP by sample in each group: non-TB non-anemic, used as control (light green); non-TB anemic (dark green); TB non-anemic (light purple); and TB anemic (dark purple). DIP score values were compared between groups according to TB and anemia status. Lines in the scatter plots represent median values and data were compared using the Mann–Whitney U test. **p < 0.01; ***p < 0.001. (C) Top 10 biomarker score of perturbation in the comparison non-TB vs TB. The score was obtained using DIP approach. (D) Poisson regression to identify biomarker measurements independently associated with increases of DIP score in HIV-TB participants. All parameters are log2 transformed. Only significant parameters are shown.