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. 2022 Jun 23;16:938674. doi: 10.3389/fnins.2022.938674

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Copyright © 2022 Chen, Pan, Meng, Xu, Huang, Pu, Yu, Wu, Lyu and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DTI images and DTT of sciatic nerves for RS3-EPI, RS5-EPI, and RS7-EPI. The RS5-EPI images displayed clearer nerve boundaries and minimum nerve distortion, while RS7-EPI showed severe nerve distortion and blurred nerve boundaries (A–F). The FA maps (G–L) and RD maps (M–O) showed blurred boundaries of RS3-EPI due to poor SNR (G,J,M) and of RS5-EPI due to severe nerve distortion (I,L,O). The ventral and dorsal margin artifacts and background noise for RS3-EPI were more pronounced (D,G,J). DTT: RS5-EPI DTI can generate more fibers than RS3-EPI and RS7-EPI and display nerve fibers with a more condensed bundle and realistic architecture (P–R). Conversely, fibers generated by RS3-EPI and RS7-EPI DTI were sparse and discrete, some of which were deviated and in random order. R: right hind limb; L: left hind limb. Scale: 2 mm.