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. 2022 Jun 23;13:893803. doi: 10.3389/fimmu.2022.893803

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Copyright © 2022 van Unen, Ouboter, Li, Schreurs, Abdelaal, Kooy-Winkelaar, Beyrend, Höllt, Maljaars, Mearin, Mahfouz, Witte, Clemens, Abraham, Escher, Lelieveldt, Pascutti, van der Meulen – de Jong and Koning

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HSNE identifies major immune lineages in blood and intestine. (A) Experimental approach (B) Graph showing absolute number of CD45⁺ immune cells acquired from 99 intestinal biopsies of the primary cohort. Bars indicate the median with interquartile range. ^*p≤0.05, ^***p≤0.001, Kruskal Wallis test for multiple groups. (C) Overview HSNE embedding of 7.7 million immune cells. Color represents the major lineages. (D) t-SNE analysis (% of CD45⁺ cells) of clustered cells for 133 samples and 7 internal control (IC) replicate samples. Every dot represents a sample, and the color and number display 34 individuals and the IC. t-SNE analysis (% of CD45+ cells) of clustered cells for 133 samples and 7 internal control (IC) replicate (green arrow) samples.