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. 2022 Jun 23;13:893803. doi: 10.3389/fimmu.2022.893803

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Copyright © 2022 van Unen, Ouboter, Li, Schreurs, Abdelaal, Kooy-Winkelaar, Beyrend, Höllt, Maljaars, Mearin, Mahfouz, Witte, Clemens, Abraham, Escher, Lelieveldt, Pascutti, van der Meulen – de Jong and Koning

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The CD4⁺ T cell lineage dissected into distinct cell subsets. (A) Heatmaps showing characteristics of 9 CD4⁺ T cell subsets (marker expressions; rainbow scale), cell subset composition of intestinal samples (cell percentages; green-to-yellow scale), clinical metadata and hierarchical clustering of marker expression profiles. (B) Graph showing cell frequency of HLA-DR⁺CD38⁺ EM CD4⁺ T cell cluster for 99 intestinal biopsies of the primary cohort. Bars indicate the median with interquartile range. ^*p≤0.05, ^***p≤0.001, Kruskal Wallis test for multiple groups. (C) t-SNE embedding showing 61,930 cells colored for the expression values of the indicated markers.