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. 2022 Jun 23;13:918928. doi: 10.3389/fimmu.2022.918928

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Copyright © 2022 Wnuk, Sudol, Spilman and Soon-Shiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of per-HLA aggregate binder count fraction at pan-HLA hotspots illustrated for all HLAs across all unique versions of S and N. All plots were sorted according to sum fraction of binders lost, such that proteins with the most loss appear on the left. Each plot has 5 vertical black lines indicating average bind loss per HLA thresholds at 0.01, 0.005, 0.002, 0.001, and 0. For compactness, binder count fractions in data only from March 13, 2021 are shown here: HLA-I binder count fractions for all unique versions of (A) S and (B) N; and HLA-II binder count fractions for (C) S and (D) N variants. Interactive plots from all data sample times are available online.