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. 2022 Jun 23;13:918928. doi: 10.3389/fimmu.2022.918928

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Copyright © 2022 Wnuk, Sudol, Spilman and Soon-Shiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of binder count fraction relative to reference SARS-CoV-2 at pan-HLA hotspots for VOC and VOI lineages. The box plots illustrate the distribution of HLA-I (A, B) and HLA-II (C, D) binder count fraction averaged across HLAs (y-axis) at S (A, C) and N (B, D) pan-HLA hotspots (x-axis) for all unique proteins classified as VOC and VOI lineages. Binder count fractions specific to the most frequent protein versions of each lineage are annotated with an ‘X’ on top of the box plots. VOC and VOI lineage labels are indicated in the legend at right.