Table 1. Sample Overview and Comparison of Maternal Pregnancy-Related Factors in the Full and Genotyped Norwegian Mother, Father and Child Cohort Study Cohort.
| Characteristic | Full sample, No. (%) | Genotyped sample, No. (%) | P valuea | ||
|---|---|---|---|---|---|
| No | Yes | No | Yes | ||
| Female child | 48 453 (51.2) | 46 180 (48.8) | 7418 (51.0) | 7113 (49) | .70 |
| Male child | 46180 (48.8) | 48453 (51.2) | 7113 (49.0) | 7418 (51.0) | .70 |
| Behavior and lifestyle | |||||
| Cigarette smoking | 78 208 (89.7) | 9008 (10.3) | 13 286 (91.6) | 1219 (8.4) | 8.38 × 10−17 |
| Alcohol consumption | 59 826 (68.6) | 27 390 (31.4) | 9921 (68.4) | 4584 (31.6) | .58 |
| Binge drinking | 74 841 (86.1) | 12 077 (13.9) | 12 365 (85.3) | 2138 (14.7) | .001 |
| Coffee consumption | 48 942 (56.3) | 37 976 (43.7) | 8302 (57.2) | 6201 (42.8) | .01 |
| Binge coffee drinking | 85 242 (98.1) | 1676 (1.9) | 14 307 (98.6) | 196 (1.4) | 3.78 × 10−8 |
| No supplements taken | 69 842 (80.4) | 17 076 (19.6) | 11 878 (81.9) | 2625 (18.1) | 3.00 × 10−7 |
| Folate supplement before pregnancy | 49 868 (57.9) | 36 211 (42.1) | 7877 (54.4) | 6616 (45.6) | 1.06 × 10−21 |
| Folate supplement during pregnancy | 17 863 (20.8) | 68 216 (79.2) | 2334 (16.1) | 12 159 (83.9) | 1.23 × 10−51 |
| Metabolic conditions | |||||
| Type 2 diabetes (including gestational diabetes) | 93 543 (98.7) | 1265 (1.3) | 14 365 (98.8) | 174 (1.2) | .13 |
| High blood pressure (including preeclampsia) | 83 138 (87.7) | 11 670 (12.3) | 12 549 (86.3) | 1990 (13.7) | 4.17 × 10−8 |
| Hyperthyroidism/hypothyroidism | 84 461 (98.1) | 1618 (1.9) | 14 252 (98.3) | 241 (1.7) | .04 |
| Infectious and autoimmune diseases | |||||
| Upper respiratory tract infections | 75 768 (86.9) | 11 448 (13.1) | 12 666 (87.3) | 1839 (12.7) | .08 |
| Lower respiratory tract infections | 84 625 (97.0) | 2591 (3) | 14 116 (97.3) | 389 (2.7) | .03 |
| Urinary tract infection | 78 843 (90.4) | 8373 (9.6) | 13 107 (90.4) | 1398 (9.6) | .88 |
| Fever | 73 832 (84.7) | 13 384 (15.3) | 12 271 (84.6) | 2234 (15.4) | .85 |
| Asthma | 83 360 (95.9) | 3558 (4.1) | 13 924 (96.0) | 579 (4) | .52 |
| Psoriasis | 84 600 (98.3) | 1479 (1.7) | 14 233 (98.2) | 260 (1.8) | .46 |
| Type 1 diabetes | 94 432 (99.6) | 376 (0.4) | 14 484 (99.6) | 55 (0.4) | .76 |
| Other autoimmune disease | 84 827 (98.5) | 1252 (1.5) | 14 276 (98.5) | 217 (1.5) | .66 |
| Other physical health conditions | |||||
| Vaginal bleeding | 94 640 (99.8) | 168 (0.2) | 14 513 (99.8) | 26 (0.2) | >.99 |
| Vitamin B12 insufficiency | 84 346 (98.0) | 1733 (2) | 14 229 (98.2) | 264 (1.8) | .08 |
| Anemia/low hemoglobin in early pregnancy | 83 601 (97.1) | 2478 (2.9) | 14 130 (97.5) | 363 (2.5) | .003 |
| Indication for medicine use | |||||
| Depression/anxiety | 77 251 (88.9) | 9667 (11.1) | 13 180 (90.9) | 1323 (9.1) | 5.42 × 10−17 |
| Depression medication | 85 868 (98.8) | 1050 (1.2) | 14 361 (99.0) | 142 (1) | .006 |
| Depression or anxiety medication | 85 627 (98.5) | 1291 (1.5) | 14 328 (98.8) | 175 (1.2) | .003 |
| Pain | 24 432 (28.1) | 62 487 (71.9) | 3946 (27.2) | 10 557 (72.8) | .008 |
| Migraine | 89 935 (94.9) | 4873 (5.1) | 13 753 (94.6) | 786 (5.4) | .12 |
| Headache | 67 347 (78.2) | 18 733 (21.8) | 11 320 (78.1) | 3173 (21.9) | .68 |
| Epilepsy | 85 816 (99.7) | 263 (0.3) | 14 456 (99.7) | 37 (0.3) | .26 |
| Pain medication | 81 093 (93.3) | 5825 (6.7) | 13 588 (93.6) | 915 (6.3) | .04 |
| Fever medication | 84 579 (98.3) | 1500 (1.7) | 14 243 (98.3) | 250 (1.7) | .89 |
| Pain or fever medication | 79 763 (91.8) | 7155 (8.2) | 13 369 (92.2) | 1134 (7.8) | .049 |
| Paracetamol use | 42 927 (49.4) | 43 991 (50.6) | 7031 (48.5) | 7472 (51.5) | .02 |
| Ibuprofen use | 80 433 (92.5) | 6485 (7.5) | 13 362 (92.1) | 1141 (7.9) | .04 |
a
P values from χ2 test comparing the genotyped sample with the nongenotyped sample. Multiple testing correction threshold was P < .002. Unless otherwise specified, the variables were measured during pregnancy.