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. 2022 Jun 23;12:868429. doi: 10.3389/fonc.2022.868429

Table 4.

Adverse events between the two treatment groups.

Variable RFA-Sorafenib (n = 103) RFA (n = 108) P-value
Grade 1–2/3–4 (%/%)
Pain 52/2 (50.5/1.9) 59/4 (54.6/3.7) 0.518
Pleural effusion 1/2 (1.0/1.9) 1/1 (0.9/0.9) 1.000
Gastrointestinal bleeding 1/2 (1.0/1.9) 1/1 (0.9/0.9) 1.000
Fever 19/2 (18.4/1.9) 22/0 (20.4/0) 0.233
Hand-foot skin reactions 27/10 (26.2/9.7) 0/0 (0/0)
Diarrhea 43/9 (41.7/8.7) 0/0 (0/0)
Hypertension 21/4 (20.4/3.9) 0/0 (0/0)
Alopecia 18/4 (17.5/3.9) 0/0 (0/0)
Nausea/vomiting 48/2 (46.6/1.9) 0/0 (0/0)
Fatigue 29/8 (28.2/7.8) 0/0 (0/0)
Dysphonia 6/1 (5.8/1.0) 0/0 (0/0)
Decreased appetite 45/9 (43.7/8.7) 0/0 (0/0)
Pyrexia 18/1 (17.5/1.0) 0/0 (0/0)
Rash 22/1 (21.4/1.0) 0/0 (0/0)
Weight decreased 19/1 (18.4/1.0) 0/0 (0/0)
Headache 8/1 (7.8/1.0) 0/0 (0/0)
ALT increased 40/11 (38.8/10.7) 0/0 (0/0)
Hyperbilirubinemia 19/2 (18.4/1.9) 0/0 (0/0)
Constipation 13/1 (12.6/1.0) 0/0 (0/0)
Oral mucositis 15/1 (14.6/1.0) 0/0 (0/0)

RFA, radiofrequency ablation; ALT, alanine aminotransferase.