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. 2022 Jun 23;12:901433. doi: 10.3389/fcimb.2022.901433

Table 2.

List of immunological molecules and their potential to differentiate children with sepsis from clinical malaria and febrile controls.

Cytokines AUC Clinical malaria Febrile controls P-value Sensitivity Specificity Cut off (pg/ml) P-value AUC Sensitivity Specificity Cut off (pg/ml)
IL-1β 0.78 0.91 0.64 <32.6 *** 0.77 0.65 0.78 >31.09 **
IL-1RA 0.75 0.52 0.88 <2623 ** 0.76 0.83 0.67 >1717 **
IL-7 0.69 0.61 0.67 <118.6 * 0.92 0.61 1.00 >118.6 ****
IL-12 0.74 0.61 0.79 <88.5 ** 0.75 0.65 0.78 >46.7 **
Chemokines AUC Sensitivity Specificity Cut off (pg/ml) P-value AUC Sensitivity Specificity Cut off (pg/ml) P-value
CCL4 0.9 0.7 0.91 <282.9 **** 0.79 0.91 0.67 >81 ***
CCL5 0.96 0.88 0.96 <275.5 **** 0.82 0.92 0.71 >103.7 **
CXCL10 0.86 0.75 0.85 <77.8 **** 0.82 0.75 0.89 >26.51 ***

*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.