Table 1.

Microbiological and clinical responses in 7 dogs with multi-drug resistant infections treated with activated MSC.

Dog	Infection site	Infection duration prior to study entry	Conncurrent antibiotic	Bacterial species isolated	Clinical response at 8 weeks	Bacteriologic response at 8 weeks
1	Post op limb spare surgical site dehiscence	1 year	Cephalexin	MRSP PR	Responder−50% wound contraction	Non-responder–Proteus and MRSP decreased by 10%
2	Post op wound repair dehiscence	6 weeks	Marbofloxacin, Chloramphenicol	MRSP PA	Responder−75% wound contraction	Responder–eliminated infection
3	Post op wound repair dehiscence	8 weeks	Amoxicillin/ clavulanic acid, Marbofloxacin	MRSP PA EC	Responder–fully healed	Responder–eliminated infection
4	Decubital ulcer	4 weeks	NA	MRSP	Responder−80% contraction of wound	Non-responder–no change in quantitative count
5	Wound antebrachium	8 weeks	Chloramphenicol, Enrofloxacin	MRSP	Responder–fully healed	Responder–eliminated infection
6	Infection in tibiotarsal joint	6 months	Clindamycin	MRSP	Responder–joint cytology normal at 8 weeks	Responder–eliminated infection
7	Nasal infection following radiation therapy	1 year	Marbofloxacin	MRSP EC, Entc, Strep	Non-responder−10% improvement in nasal score	Partial responder–eliminated all bacteria but MRSP
8	Nasal infection following radiation therapy	1 year	Trimethoprim Sulfamethoxazole	MRSP, EC, Entc, Kleb pn, Crn	Responder−50% improvement in nasal score	Partial responder–eliminated all bacteria except MRSP and EC

Organisms isolated from the wounds are abbreviated as follows: MRSP, methicillin resistant Staphylococcus pseudointermedius; EC, Escherichia coli; PA, Pseudomonas aeruginosa; Crn, Corynebacterium species; PR, Proteus species; Ent, Enterobacter species; Entc, Enterococcus species; Strep, Streptococcus species; Kleb pn, Klebsiella pneumoniae.