Figure 2.

Hematological parameters of rhesus monkeys infected with P. knowlesi. (A) Longitudinal faceted plots showing parasitemia, with treatment threshold and control interval indicated, compared with (B) white blood cell count with population fractions indicated, (C) hemoglobin with mild, moderate, and severe anemia thresholds labeled (at 11 g/dL, 10 g/dL, and 7 g/dL, respectively), with (D) five day hemoglobin average, (E) platelet count with mild and moderate thrombocytopenia labeled (at 150,000 platelets/mL and 75,000 platelets/μL, respectively), with (F) five day platelet average, (G) reticulocyte production index (with RPI of 2 and of 3 labeled), and (H) five-day average of reticulocyte counts. (I) 600x H&E-stained tissue sections of bone marrow from an uninfected control monkey, a monkey prior to controlling parasitemia, and a monkey after controlling parasitemia. (J) Erythopoietin levels from select monkeys demonstrating no difference between baseline and 10 dpi, prior to antimalarial treatment. (K) Mathematical modeling predicting the relative proportions of infected and uninfected red blood cell removal. Statistical comparisons were performed using paired t-tests. ***p-value < 0.0005, *p-value < 0.05, and ns (not significant) = p-value > 0.05. Error bars represent standard error of the mean.