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. 2022 Jun 23;13:909870. doi: 10.3389/fphys.2022.909870

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Copyright © 2022 Schillemans, Tragante, Maitusong, Gigante, Cresci, Laguzzi, Vikström, Richards, Pilbrow, Cameron, Foco, Doughty, Kuukasjärvi, Allayee, Hartiala, Tang, Lyytikäinen, Nikus, Laurikka, Srinivasan, Mordi, Trompet, Kraaijeveld, van Setten, Gijsberts, Maitland-van der Zee, Saely, Gong, Johnson, Cooper-DeHoff, Pepine, Casu, Leiherer, Drexel, Horne, van der Laan, Marziliano, Hazen, Sinisalo, Kähönen, Lehtimäki, Lang, Burkhardt, Scholz, Jukema, Eriksson, Åkerblom, James, Held, Hagström, Spertus, Algra, de Faire, Åkesson, Asselbergs, Patel and Leander.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Panel (A): Meta-analyses of the associations between rs8192673 (G482S) in the PPARGC1A gene and the primary outcome (CHD death or myocardial infarction) in participants with baseline CHD within GENIUS-CHD using an additive, fixed-effect model stratified for patient-level characteristics. LV, left ventricular. Panel (B): Meta-analyses of the associations between rs7672915 (intron 2) in the PPARGC1A gene and the primary outcome (CHD death or myocardial infarction) in participants with baseline CHD within GENIUS-CHD using an additive, fixed-effect model stratified for patient-level characteristics. LV, left ventricular. Panel (C): Meta-analyses of the associations between rs3755863 (T528T) in the PPARGC1A gene and the primary outcome (CHD death or myocardial infarction) in participants with baseline CHD within GENIUS-CHD using an additive, fixed-effect model stratified for patient-level characteristics. LV, left ventricular.