Table 1. Antiviral Activity of Apratoxin S4 against SARS-CoV-2, Flaviviruses, and Influenza.
| viruses | cell line | IC50 (nM) | CC50 (μM) | SI |
|---|---|---|---|---|
| SARS-CoV-2 USA-WA1/2020 | Vero E6 | 170 | >10 | >58 |
| SARS-CoV-2 USA-WA1/2020 | HeLa-hACE2 | 0.71 | >1 | >1400 |
| Zika virus/Ugandan MR766 | Huh-7.5 | 15 | >1 | >67 |
| West Nile virus/Kunjin isolate | Huh-7.5 | 14 | >1 | >71 |
| Dengue virus/16681 serotype 2 | Huh-7.5 | 3.3 | >1 | >300 |
| Influenza A virus/WSN | A549 | 0.46 | >1 | >2200 |