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. 2022 Jun 24;24(2):280. doi: 10.3892/ol.2022.13400

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Copyright: © Luo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — PVT1 regulates colon cancer cell 5-FU resistance via the miR-486-5p/CDK4 axis. Reverse transcription-quantitative PCR was used to detect (A) PVT1, (B) miR-486-5p and (C) CDK4 expression in HCT116-5-FU-resistant cells overexpressing miR-486-5p and CDK4, or in cells in which PVT1 expression was knocked down. (D) Western blot analysis was performed to detect CDK4 protein levels following the overexpression of miR-486-5p, and CDK4, or PVT1 knockdown in HCT116-5-FU-resistant cells. *P<0.05. PVT1, plasmacytoma variant translocation 1; 5-FU, 5-fluorouracil.